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1

Targeting brain aminopeptidase A, a new strategy for the treatment of hypertension and heart failure

Marc, Yannick, Boitard, SolÃ¨ne Emmanuelle, Balavoine, Fabrice, Azizi, Michel, Llorens-Cortes, Catherine

Journal:

Canadian Journal of Cardiology

Year:

2020

File:

PDF, 2.08 MB

2020

2

Angiotensin III: a central regulator of vasopressin release and blood pressure

Annabelle Reaux, Marie Claude Fournie-Zaluski, Catherine Llorens-Cortes

Journal:

Trends in Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

3

Study of Asparagine 353 in Aminopeptidase A: Characterization of a Novel Motif (GXMEN) Implicated in Exopeptidase Specificity of Monozinc Aminopeptidases

Iturrioz, Xavier, Rozenfeld, Raphaël, Michaud, Annie, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Year:

2001

Language:

english

File:

PDF, 269 KB

english, 2001

4

NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Keck, Mathilde, De Almeida, Hugo, Compère, Delphine, Inguimbert, Nicolas, Flahault, Adrien, Balavoine, Fabrice, Roques, Bernard, Llorens-Cortes, Catherine

Journal:

Year:

2019

File:

PDF, 514 KB

2019

5

Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions

Keck, Mathilde, Hmazzou, Reda, Llorens-Cortes, Catherine

Journal:

Current Hypertension Reports

Year:

2019

File:

PDF, 1.01 MB

2019

6

Evolution of a New Class of Antihypertensive Drugs

Llorens-Cortes, Catherine, Touyz, Rhian M.

Journal:

Year:

2020

File:

PDF, 946 KB

2020

7

Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain

Lenkei, Zsolt, Palkovits, Miklos, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

The Journal of Comparative Neurology

Year:

1996

Language:

english

File:

PDF, 2.16 MB

english, 1996

8

Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain

Anne Monique Nuyt, Zsolt Lenkei, Miklos Palkovits, Pierre Corvol, Catherine Llorens-Cortés

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 986 KB

english, 1999

9

Ontogeny of angiotensin II type 1 receptor mRNAs in fetal and neonatal rat brain

Anne Monique Nuyt, Zsolt Lenkei, Pierre Corvol, Miklós Palkovits, Catherine Llorens-Cortés

Journal:

The Journal of Comparative Neurology

Year:

2001

Language:

english

File:

PDF, 832 KB

english, 2001

10

Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control

Patrick Vicart, Patrice Testut, Bertrand Schwartz, Catherine Llorens-Cortes, Juana J. Perdomo, Denise Paulin

Journal:

Journal of Cellular Physiology

Year:

1993

Language:

english

File:

PDF, 1.36 MB

english, 1993

11

Synthesis and separation of tritiated inhibitors of aminopeptidase A and their prodrugs

Nicolas Inguimbert, Pascale Coric, Hélène Dhotel, Catherine Llorens-Cortes, Marie-Claude Fournié-Zaluski, Bernard P. Roques

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

12

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain

Annabelle Reaux, Nadia De Mota, Ivana Skultetyova, Zsolt Lenkei, Said El Messari, Katalin Gallatz, Pierre Corvol, Miklos Palkovits, Catherine Llorens-Cortès

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 665 KB

english, 2001

13

Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron

Hus-Citharel, Annette, Gasc, Jean-Marie, Zini, Sylvie, Marchetti, Jeannine, Roques, Bernard, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Kidney International

Year:

1999

Language:

english

File:

PDF, 799 KB

english, 1999

14

Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb

Hus-Citharel, Annette, Marchetti, Jeannine, Corvol, Pierre, Llorens-Cortes, Catherine

Journal:

Kidney International

Year:

2002

Language:

english

File:

PDF, 439 KB

english, 2002

15

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David, Laurent Bischoff, Hervé Meudal, Catherine Llorens-Cortes, Bernard Pierre Roques, Marie-Claude Fournié-Zaluski

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 229 KB

english, 1997

16

Aminopeptidase A inhibitors as centrally acting antihypertensive agents

Laurence Bodineau, Alain Frugière, Yannick Marc, Cédric Claperon, Catherine Llorens-Cortes

Journal:

Heart Failure Reviews

Year:

2008

Language:

english

File:

PDF, 429 KB

english, 2008

17

Role of angiotensin III in hypertension

Annabelle Reaux-Le Goazigo, Xavier Iturrioz, Celine Fassot, Cedric Claperon, Bernard P. Roques, Catherine Llorens-Cortes

Journal:

Current Hypertension Reports

Year:

2005

Language:

english

File:

PDF, 987 KB

english, 2005

18

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons

Dan D. Feng, Seung-Kwon Yang, Catherine Loudes, Axelle Simon, Tamara Al-Sarraf, Michael Culler, Rodrigo Alvear-Perez, Catherine Llorens-Cortes, Chen Chen, Jacques Epelbaum, Robert Gardette

Journal:

European Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

19

A Novel Potential Metallopeptidase Derived from the Enkephalinase Gene by Alternative Splicing

Catherine Llorens-Cortes, Bruno Giros, Jean-Charles Schwartz

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 351 KB

english, 1990

20

Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure

Said El Messari, Xavier Iturrioz, Celine Fassot, Nadia De Mota, Darren Roesch, Catherine Llorens-Cortes

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

21

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

Nadia De Mota, Xavier Iturrioz, Cedric Claperon, Laurence Bodineau, Celine Fassot, Bernard Pierre Roques, Miklos Palkovits, Catherine Llorens-Cortes

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 698 KB

english, 2008

22

Ontogeny of angiotensin II type 2 (AT2) receptor mRNA in the rat

Shanmugam, Sadoutounissa, Lenkei, Zsolt G, Gasc, Jean-Marie R, Corvol, Pierre L, Llorens-Cortes, Catherine M

Journal:

Kidney International

Year:

1995

Language:

english

File:

PDF, 719 KB

english, 1995

23

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David, Laurent Bischoff, Hervé Meudal, Catherine Llorens-Cortes, Bernard Pierre Roques, Marie-Claude Fournié-Zaluski

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 94 KB

english, 1997

24

Roles of brain angiotensins II and III in thirst and sodium appetite

Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, Joseph W. Harding, John W. Wright

Journal:

Year:

2005

Language:

english

File:

PDF, 432 KB

english, 2005

25

The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions

Nicolas Chartrel, Jessy Alonzeau, David Alexandre, Lydie Jeandel, Rodrigo Alvear-Perez, Jérôme Leprince, Jean Boutin, Hubert Vaudry, Youssef Anouar, Catherine Llorens-Cortes

Journal:

Frontiers in Neuroendocrinology

Year:

2011

Language:

english

File:

PDF, 509 KB

english, 2011

26

Effects of angiotensin II and antagonists on AT1 receptor expression in mesangial cells

Dominique Chansel, Sophie Vandermeersch, Catherine Llorens-Cortes, Raymond Ardaillou

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 688 KB

english, 1999

27

Production and properties of a recombinant soluble form of aminopeptidase A

Gilles Vazeux, Sherwin Wilk, Elizabeth Wilk, Pierre Corvol, Catherine Llorens-Cortès

Journal:

Year:

1998

Language:

english

File:

PDF, 460 KB

english, 1998

28

Apelin and Vasopressin: Two Work Better than One

Catherine Llorens-Cortes, Francoise Moos

Journal:

Journal of Neuroendocrinology

Year:

2012

Language:

english

File:

PDF, 122 KB

english, 2012

29

Enkephalinase activity in rat peripheral organs

Catherine Llorens, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1981

Language:

english

File:

PDF, 261 KB

english, 1981

30

Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin

Catherine Llorens-Cortes, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 388 KB

english, 1984

31

Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: Validation of a radioimmunoassay, localisation and effects of peptidase inhibitors

Catherine Llorens-Cortes, Claude Gros, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 677 KB

english, 1985

32

Inhibition of enkephalin degradation by phelorphan: effects on striatal [Met5]enkephalin levels and jump latency in mouse hot plate test

Jan G.C. Van Amsterdam, Catherine Llorens-Cortes

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 457 KB

english, 1988

33

Detection of the tripeptide Tyr-Gly-Gly, a putative enkephalin metabolite in brain, using a sensitive radioimmunoassay

Catherine Llorens-Cortes, Jean-Charles Schwartz, Claude Gros

Journal:

Year:

1985

Language:

english

File:

PDF, 321 KB

english, 1985

34

The role of the brain renin–angiotensin system in hypertension: Implications for new treatment

Yannick Marc, Catherine Llorens-Cortes

Journal:

Progress in Neurobiology

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

35

Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry

Zsolt Boldogköi, Aniko Reichart, Ida E Tóth, Attila Sik, Ferenc Erdélyi, Istvan Medveczky, Catherine Llorens-Cortes, Miklos Palkovits, Zsolt Lenkei

Journal:

Molecular Brain Research

Year:

2002

Language:

english

File:

PDF, 1.07 MB

english, 2002

36

Investigation of the Active Site of Aminopeptidase A Using a Series of New Thiol-Containing Inhibitors

Chauvel, Eric N., Coric, Pascale, Llorens-Cortes, Catherine, Wilk, Sherwin, Roques, Bernard P., Fournie-Zaluski, Marie-Claude

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.06 MB

english, 1994

37

Rational design of enkephalinase inhibitors: Substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides

Catherine Llorens, Gilles Gacel, Jean-Paul Swerts, Rémi Perdrisot, Marie-Claude Fournie-Zaluski, Jean-Charles Schwartz, Bernard P. Roques

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 435 KB

english, 1980

38

Endorphins in several regions of rat brain: Large differences between radioimmunoassay and radioreceptor assay

Catherine Llorens-Cortes, Helene Pollard, Jean-Charles Schwartz, Philippe Pradelles, Claude Gros, Fernand Dray

Journal:

European Journal of Pharmacology

Year:

1977

Language:

english

File:

PDF, 144 KB

english, 1977

39

Differential recognition of “enkephalinase” and angiotensin-converting enzyme by new carboxyalkyl inhibitors

Marie-Claude Fournié-Zaluski, Evelyne Soroca-Lucas, Gilles Waksman, Catherine Llorens, Jean-Charles Schwartz, Bernard P. Roques

Journal:

Year:

1982

Language:

english

File:

PDF, 541 KB

english, 1982

40

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase

Balavoine, Fabrice, Azizi, Michel, Bergerot, Damien, Mota, Nadia, Patouret, Rémi, Roques, Bernard P., Llorens-Cortes, Catherine

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 552 KB

english, 2014

41

The endogenous tripeptide Tyr-Gly-Gly as a possible metabolite of opioid peptides in rat brain: Identification, regional distribution, effects of lesions and formation in depolarized slices

Giros, Bruno, Llorens-Cortes, Catherine, Gros, Claude, Schwartz, Jean-Charles

Journal:

Year:

1986

Language:

english

File:

PDF, 862 KB

english, 1986

42

Enkephalinase (EC 3.4.24.11) is highly localized to a striatonigral pathway in rat brain

Pollard, Hélène, Llorens-Cortes, Catherine, Couraud, Jean-Yves, Ronco, Pierre, Verroust, Pierre, Schwartz, Jean-Charles

Journal:

Neuroscience Letters

Year:

1987

Language:

english

File:

PDF, 337 KB

english, 1987

43

Steady-State Level and Turnover Rate of the Tripeptide Tyr-Gly-Gly as Indexes of Striatal Enkephalin Release in vivo and Their Reduction during Pentobarbital Anesthesia

Catherine Llorens-Cortes, Claude Gros and Jean-Charles Schwartz

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 962 KB

english, 1986

44

Identification of Metabolic Pathways of Brain Angiotensin II and III Using Specific Aminopeptidase Inhibitors: Predominant Role of Angiotensin III in the Control of Vasopressin Release

Sylvie Zini, Marie-Claude Fournie-Zaluski, Eric Chauvel, Bernard P. Roques, Pierre Corvol and Catherine Llorens-Cortes

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.64 MB

english, 1996

45

Aminopeptidase A Inhibitors as Potential Central Antihypertensive Agents

Annabelle Reaux, Marie Claude Fournie-Zaluski, Christelle David, Sylvie Zini, Bernard P. Roques, Pierre Corvol and Catherine Llorens-Cortes

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.29 MB

english, 1999

46

High frequency gamma activity in the left hippocampus predicts visual object naming performance

Hamamé, Carlos M., Alario, F.-Xavier, Llorens, Anais, Liégeois-Chauvel, Catherine, Trébuchon-Da Fonseca, Agnés

Journal:

Brain and Language

Year:

2014

Language:

english

File:

PDF, 2.87 MB

english, 2014

47

Histidine 450 Plays a Critical Role in Catalysis and, with Ca 2+ , Contributes to the Substrate Specificity of Aminopeptidase A

Iturrioz, Xavier, Vazeux, Gilles, Célérier, Jérôme, Corvol, Pierre, Llorens-Cortès, Catherine

Journal:

Year:

2000

Language:

english

File:

PDF, 96 KB

english, 2000

48

Differential Inhibition of Aminopeptidase A and Aminopeptidase N by New .beta.-Amino Thiols

Chauvel, Eric N., Llorens-Cortes, Catherine, Coric, Pascale, Wilk, Sherwin, Roques, Bernard P., Fournie-Zaluski, Marie-Claude

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

49

Potent and Selective Inhibition of Zinc Aminopeptidase A (EC 3.4.11.7, APA) by Glutamyl Aminophosphinic Peptides: Importance of Glutamyl Aminophosphinic Residue in the P 1 Position †

Georgiadis, Dimitris, Vazeux, Gilles, Llorens-Cortes, Catherine, Yiotakis, Athanasios, Dive, Vincent

Journal:

Year:

2000

Language:

english

File:

PDF, 86 KB

english, 2000

50

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

David, Christelle, Bischoff, Laurent, Meudal, Hervé, Mothé, Aurélie, De Mota, Nadia, DaNascimento, Sophie, Llorens-Cortes, Catherine, Fournié-Zaluski, Marie-Claude, Roques, Bernard P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 371 KB

english, 1999

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